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The most serious complication of OLP is oral squamous cell carcinoma. The prevalence of OLP in the normal adult population is 0.49–1.43%. It is one of the most common diseases in oral medicine clinics. Oral lichen planus (OLP) is a chronic T-lymphocyte mediated inflammatory disorder, which presents in two primary clinical categories: white forms (reticular, papular, plaquelike) and red forms (erosive, atrophic, bullous). The red-form OLP might be associated with damage or reduction of kidney function. These findings indicate MPV might play roles in inflammation in OLP. Besides, 75% of the OLP patients were overweight with body mass index (BMI) more than 25 kg/m 2.
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In terms of C-reactive protein (CRP), 92.5% of the OLP patients had a value of less than 3.48 mg/L. By contrast, there were no differences between those two groups in the other variables including MPV, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine.
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Red-form OLP group had increased blood urea nitrogen (BUN, 5.24 ± 1.15 mmol/L versus 4.69 ± 0.98 mmol/L, P = 0.036) than white-form OLP group. MPV was elevated in OLP patients compared to controls (10.68 ± 0.97 fL versus 10.33 ± 0.89 fL, P = 0.042) while platelet count showed no difference between them.
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Data on full blood count and biochemical tests were obtained from the electronic medical record system of the hospital. MethodsĮighty pathologically confirmed OLP patients and 51 healthy controls were enrolled. This retrospective observational study aims to assess platelet count, mean platelet volume (MPV), blood biochemical tests for liver and kidney function in Chinese oral lichen planus (OLP) patients.